Kineta Receives Regulatory Approval for Initiation of Phase 1 Clinical Trials of KCP506v

Aug 11, 2020

SEATTLE, Aug. 12, 2020  /PR Newswire/ -- Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology, neuroscience and biodefense announced today the Clinical Trial Application (CTA) approval in the Netherlands for initiation of a first in-human clinical trial of KCP506.  KCP506 is a first-in-class α9α10 nicotinic acetylcholine receptor (nAChR) antagonist in development for the treatment of chronic neuropathic pain. 

A double-blind, placebo-controlled, single ascending dose and multiple ascending dose study will be conducted in healthy subjects to evaluate the safety, tolerability, and pharmacokinetics of KCP506.  The company is planning to initiate the Phase 1 clinical trials of KCP506 in Q4 2020. 

"CTA approval of KCP506 marks a critical milestone for Kineta as we prepare to evaluate our novel non-opioid in the clinic," said Kineta CEO Shawn Iadonato.  "There is a tremendous unmet need for patients with chronic pain, and we believe that KCP506 has the potential to be a disease modifying therapy without CNS related side effects including addiction." 

KCP506 is a novel α9α10 nAChR antagonist in development for the treatment of chronic neuropathic pain. α9α10 nAChR antagonists have demonstrated robust analgesic, anti-neuroinflammatory and neuroprotective effects across multiple preclinical chronic pain models.  KCP506 offers the potential for a disease modifying therapy that may slow or halt the progression of chronic pain.  KCP506 may potentially be an effective treatment for many types of chronic neuropathic pain including radiculopathy, chemotherapy-induced peripheral neuropathy and diabetic neuropathy. The global neuropathic pain market was $6.3 billion in 2019 and is expected to reach to $9.9 billion by 2027. Kineta established a strategic partnership in April 2018 with Genentech, a member of the Roche Group. The research collaboration is focused on developing first in class α9α10 nAChR antagonists for the treatment of chronic pain.

Kineta, Inc. is a clinical stage biotechnology company committed to developing disruptive life science technologies that address unmet patient needs.  We have leveraged our expertise in immunology to advance a focused pipeline of investigational drugs in oncology, neuroscience and biodefense.  We actively collaborate with a broad array of private, government and industry partners to advance our innovative products.  For more information on Kineta visit our website, www.kinetabio.com, follow us on Twitter at @kinetabio, LinkedIn and Like us on facebook.com/KinetaBio.

NOTICE: This document contains certain forward-looking statements, including without limitation statements regarding Kineta's and Kineta Chronic Pain, LLC's (KCP) plans for pre-clinical and clinical studies, regulatory filings, investor returns and anticipated drug effects in human subjects. You are cautioned that such forward-looking statements are not guarantees of future performance and involve risks and uncertainties inherent in Kineta's and KCP's businesses which could significantly affect expected results, including without limitation progress of drug development, ability to raise capital to fund drug development, clinical testing and regulatory approval, developments in raw material and personnel costs, and legislative, fiscal, and other regulatory measures. All forward-looking statements are qualified in their entirety by this cautionary statement, and neither Kineta nor KCP undertake any obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Contact Jacques Bouchy
[email protected] 
(206) 378-0400

SOURCE Kineta, Inc.

Related Links

http://www.kinetabio.com

More News

Pending US$12.3 million house arrest fine keeps Malaysia’s Najib in prison
Sep 20, 2026
Pending US$12.3 million house arrest fine keeps Malaysia’s Najib in prison

Former Malaysian prime minister Najib Razak said on Sunday that he would remain in Kajang Prison as he and his legal team study the conditions attached to his “conditional pardon”, including the payment of a 50 million ringgit (US$12.3 million) fine before he can be transferred to house arrest. In a statement issued on his behalf by Messrs Shafee & Co, Najib said his transfer to house arrest depended on the conditions of the pardon being fulfilled. “Until the fine is paid to the court, our...

A Diplomat From Myanmar Refuses to Give Up New York City Post
Sep 20, 2026
A Diplomat From Myanmar Refuses to Give Up New York City Post

For more than five years, U Kyaw Moe Tun has refused to give up his United Nations post and a sandstone townhouse on the Upper East Side.

The cooling trap: how Asia’s air conditioners are making heatwaves worse
Sep 20, 2026
The cooling trap: how Asia’s air conditioners are making heatwaves worse

As heatwaves become more frequent and intense across Asia, the region faces a dangerous power paradox. Soaring demand for air conditioning threatens to push electricity grids closer to failure just as extreme heat puts the infrastructure under greater strain, raising the risk of cooling disappearing when people need it most. That risk has been visible across the region this summer. In South Korea, President Lee Jae Myung called a record heatwave a “national disaster” in August after the death...

Anwar was on song in India. Will Malaysia reap the rewards?
Sep 20, 2026
Anwar was on song in India. Will Malaysia reap the rewards?

Malaysia’s Prime Minister Anwar Ibrahim caused a bit of a stir in India recently with his spirited rendition of a Bollywood classic – a lighthearted moment that also neatly captured his broader push to deepen ties with the South Asian giant. A video of Anwar singing, from memory, Kishore Kumar’s 1965 hit ballad “Khwab Ho Tum Ya Koi Haqeeqat” (“Are you a dream or are you reality?”) was first posted to his social media accounts last Sunday before quickly being picked up by Indian news outlets. The...

Why AI giants are choosing Singapore to turn models into real-world tools
Sep 20, 2026
Why AI giants are choosing Singapore to turn models into real-world tools

When Jordan Seow joined OpenAI in June 2025, he became the company’s first locally hired forward-deployed engineer in Asia-Pacific, joining a Singapore office that then had fewer than 20 employees. The 29-year-old is now part of a fast-growing workforce built in Singapore by the world’s leading artificial intelligence companies. Experts say the city state is emerging as a regional hub – not for training the latest AI models, but for the increasingly crucial task of deploying and adapting them...

Named as an enemy: Indonesia’s uneasy Aukus moment
Sep 20, 2026
Named as an enemy: Indonesia’s uneasy Aukus moment

A former Australian official’s use of a hypothetical “aggressive Indonesia” to make the case for Aukus at a public inquiry has been called “clumsy diplomacy” by analysts, who say the comments risk reviving old suspicions as Jakarta and Canberra try to strengthen security ties. Michael Pezzullo, a former deputy secretary of strategy in Australia’s defence department, made the remarks in testimony on September 2 to the Aukus Public Inquiry, an independent, crowdfunded review of the trilateral...

‘Nervous and Skeptical,’ Greenlanders Question the New Deal With Trump
Sep 19, 2026
‘Nervous and Skeptical,’ Greenlanders Question the New Deal With Trump

The U.S. president’s threats to seize Greenland left its people on edge, and with details scarce, the news of an agreement didn’t seem to be putting minds at ease.

Group With Al Qaeda Links Claims Responsibility for Attack in Pakistan
Sep 19, 2026
Group With Al Qaeda Links Claims Responsibility for Attack in Pakistan

The attack on a mosque inside a police compound, killing at least two dozen people, is the latest example of the worsening violence near the Afghan border.

India Is Again Squeezed Between the Threat of Trump Tariffs and Russian Oil
Sep 19, 2026
India Is Again Squeezed Between the Threat of Trump Tariffs and Russian Oil

India is trying to secure affordable energy while preserving a crucial relationship with Washington, a balancing act made harder by turmoil in global energy markets.

China’s GoPro rival Insta360 opens first US flagship store in New York’s Times Square
Sep 19, 2026
China’s GoPro rival Insta360 opens first US flagship store in New York’s Times Square

Chinese action camera maker Insta360 is deepening its US footprint with a flagship store opening in New York as it navigates escalating price competition with DJI and industry-wide memory cost pressures. The Chinese GoPro rival was slated to plant its flag in the heart of Times Square with its first flagship retail store in the US on Saturday, a marquee launch as the firm looked to “leap to the next stage of growth”, co-founder Max Richter said. “The US market plays a very important role for us...

AI: 10 days that changed the course of artificial intelligence
Sep 19, 2026
AI: 10 days that changed the course of artificial intelligence

For years, the race to build ever more powerful artificial intelligence followed a well-worn Silicon ⁠Valley principle: move fast and break things. But in a series of cascading events over a 10-day stretch, the largest ⁠AI labs found themselves reeling as their own creations threatened to break humanity itself. An Anthropic researcher quit the firm, warning that the pace of AI development poses an existential threat, possibly within a decade. Another researcher at the firm said the odds of human...

Malaysia’s Loke resigns as transport minister following Najib’s house arrest approval
Sep 19, 2026
Malaysia’s Loke resigns as transport minister following Najib’s house arrest approval

A senior ally of Malaysia’s Anwar Ibrahim announced his resignation from cabinet on Saturday – a day after confidence in the prime minister’s administration took a severe hit when disgraced former leader Najib Razak was allowed to serve out his jail term under house arrest. Anthony Loke, the secretary general of the Democratic Action Party (DAP), said that the party could not accept the decision to allow Najib to complete his sentence in the comfort of his own home. The former prime minister is...

YOUR NEWS, OUR NETWORK.

Do you have Great News you want to tell the world?

Be it updates about your business or your community, you can make sure that it’s heard by submitting your story to our network reaching hundreds of news sites across 6 verticals.

Indo Inquirer

Indo Inquirer is the leading online news network in Indonesia, providing daily breaking news with in-depth news coverage and the best photojournalism. We deliver compelling and diverse engaging stories around the world.

Newsletter